As we age, lines and wrinkles around our nose and mouth are often the first to form. Patients who wish to eliminate these lines without common invasive surgery can often benefit from Restylane® Defyne to rejuvenate their facial appearance.

What is Restylane® Defyne?

Restylane® Defyne is a hyaluronic acid filler created to soften the appearance of moderate to severe nasolabial folds and marionette lines. Created with XpresHAn technology, Restylane® Defyne is created to move with the skin so patients can retain the ability to make natural-looking facial expressions and movements.

Restylane® Defyne also contains a small amount of lidocaine, so ensure patient’s comfort during injections. A topical anesthetic can also be applied if desired. Non-surgical treatments can take anywhere from 20-40 minutes to complete, depending on the size of the treatment area.

Who is a Good Candidate?

Restylane® Defyne is FDA-approved for use in adults ages 21 and older. Individuals who wish to smooth their facial lines and wrinkles can often benefit from this filler. Patients who wish to eliminate their marionette lines and nasolabial folds without undergoing surgery often choose to undergo Defyne treatments.

Restylane® Defyne Results

Following treatment, patients may experience itching, swelling, bruising, or redness at the treatment sites. Results from Restylane® Defyne can last up to 12 months.

Patients in the Denver or Lone Tree areas can contact our office today to learn more about Restylane® Defyne. Call 303-744-2300 to schedule a consultation.


Dr. Christopher Cote and Dr. Nicolette Picerno are board-certified plastic surgeons practicing in Denver and Lone Tree, Colorado. They have over 40 years of combined experience together in facial plastic surgery. Both Dr. Cote and Dr. Picerno specialize in procedures like Facelift, Browlift, Facial Rejuvenation, Nose Surgery, and many other types of cosmetic procedures at FacesFirst.

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