As we age, lines and wrinkles around our nose and mouth are often the first to form. Patients who wish to eliminate these lines without common invasive surgery can often benefit from Restylane® Defyne to rejuvenate their facial appearance.

What is Restylane® Defyne?

Restylane® Defyne is a hyaluronic acid filler created to soften the appearance of moderate to severe nasolabial folds and marionette lines. Created with XpresHAn technology, Restylane® Defyne is created to move with the skin so patients can retain the ability to make natural-looking facial expressions and movements.

Restylane® Defyne also contains a small amount of lidocaine, so ensure patient’s comfort during injections. A topical anesthetic can also be applied if desired. Non-surgical treatments can take anywhere from 20-40 minutes to complete, depending on the size of the treatment area.


from our patients

I saw Dr. Picerno and FacesFirst for a lower jaw and neck uplift. My experience with Dr. P and her staff was amazing. They were so professional and answered all my questions with ease. They were very responsive to my emails. And they helped get all of my aftercare set up for me. They went out of their way to find me the most cost effective solutions. I found that their office isn’t just cosmetic surgery. It is anything and all things for faces and I will be using them to meet my other needs. Highly, highly recommend Dr. P and her staff!

-Christy Fleskes

Dr Picerno is amazing and I adore her!
-Ciana Wallace
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Who is a Good Candidate?

Restylane® Defyne is FDA-approved for use in adults ages 21 and older. Individuals who wish to smooth their facial lines and wrinkles can often benefit from this filler. Patients who wish to eliminate their marionette lines and nasolabial folds without undergoing surgery often choose to undergo Defyne treatments.

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Restylane® Defyne Results

Following treatment, patients may experience itching, swelling, bruising, or redness at the treatment sites. Results from Restylane® Defyne can last up to 12 months.

Patients in the Denver or Lone Tree areas can contact our office today to learn more about Restylane® Defyne. Call 303-744-2300 to schedule a consultation.

Frequently Asked Questions

Can you use Restylane Defyne for nasolabial folds?

Absolutely! It is FDA-approved to specifically treat and diminish the appearance of nasolabial folds.

How long does it take for Restylane Defyne to work?

Restylane Defyne will start to work immediately, but final results will take about 1-2 weeks.

What are the benefits of Restylane Defyne?

The benefits of Restylane Defyne include a reduction in the appearance of smile lines, nasolabial folds, and deep wrinkles and folds.

How long does it take for Restylane swelling to go down?

Swelling should go down a few days after receiving injections.



Galderma – Restylane defyne

Nicolette Picerno, M.D.

Dr. Nicolette Picerno is a double-board-certified facial cosmetic surgeon certified by the American Board of Facial Plastic and Reconstructive Surgery and the American Board of Otolaryngology. She received her medical degree from Hahnemann University, School of Medicine in Philadelphia, and completed her fellowship for the American Academy of Facial Plastic and Reconstructive Surgery at the Beeson Aesthetic Surgery Institute in Carmel, IN. She also completed the Cenegenics Physician Training and Certification in Age Management Medicine program in 2012 and became a certified BioTE provider in 2014. When not in the office, Dr. Picerno enjoys spending time with her family, hiking, skiing, playing tennis, and running her doggie daycare with her husband.

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